Clinical study with glipizide, a new oral antidiabetic drug
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چکیده
منابع مشابه
Transporter-Mediated Drug–Drug Interactions with Oral Antidiabetic Drugs
Uptake transporters (e.g., members of the SLC superfamily of solute carriers) and export proteins (e.g., members of the ABC transporter superfamily) are important determinants for the pharmacokinetics of drugs. Alterations of drug transport due to concomitantly administered drugs that interfere with drug transport may alter the kinetics of drug substrates. In vitro and in vivo studies indicate ...
متن کاملDrug Transport Mechanism of Oral Antidiabetic Nanomedicines
CONTEXT Over the last few decades, extensive efforts have been made worldwide to develop nanomedicine delivery systems, especially via oral route for antidiabetic drugs. Absorption of insulin is hindered by epithelial cells of gastrointestinal tract, acidic gastric pH and digestive enzymes. EVIDENCE ACQUISITION Recent reports have identified and explained the beneficial role of several struct...
متن کاملdrug transport mechanism of oral antidiabetic nanomedicines
context: over the last few decades, extensive efforts have been made worldwide to develop nanomedicine delivery systems, especially via oral route for antidiabetic drugs. absorption of insulin is hindered by epithelial cells of gastrointestinal tract, acidic gastric ph and digestive enzymes. evidence acquisition: recent reports have identified and explained the beneficial role of several struct...
متن کاملGlipizide, an antidiabetic drug, suppresses tumor growth and metastasis by inhibiting angiogenesis
Angiogenesis is involved in the development, progression and metastasis of various human cancers. Herein, we report the discovery of glipizide, a widely used drug for type 2 diabetes mellitus, as a promising anticancer agent through the inhibition of tumor angiogenesis. By high-throughput screening (HTS) of an FDA approved drug library utilizing our in vivo chick embryo chorioallantoic membrane...
متن کاملRacial differences in long-term adherence to oral antidiabetic drug therapy: a longitudinal cohort study
BACKGROUND Adherence to oral antidiabetic medications is often suboptimal. Adherence differences may contribute to health disparities for black diabetes patients, including higher microvascular event rates, greater complication-related disability, and earlier mortality. METHODS In this longitudinal retrospective cohort study, we used 10 years of patient-level claims and electronic medical rec...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1973
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf01218445